Steele‐Richardson‐Olszewski‐Syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study
Identifieur interne : 004284 ( Main/Exploration ); précédent : 004283; suivant : 004285Steele‐Richardson‐Olszewski‐Syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study
Auteurs : Guy Arnold [Allemagne] ; Klaus Tatsch [Allemagne] ; Eduardo Kraft [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Johannes Schwarz [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Antagonist, Atrophy, Benzamide derivatives, Benzamides (diagnostic use), Corpus Striatum (metabolism), D2 Dopamine receptor, Diagnosis, Dopamine Antagonists (diagnostic use), Female, Humans, In vivo, Iodine Radioisotopes (diagnostic use), Magnetic Resonance Imaging, Male, Mesencephalon (pathology), Middle Aged, Morphometry, Nuclear magnetic resonance imaging, Pyrrolidines (diagnostic use), Receptors, Dopamine D2 (metabolism), Severity of Illness Index, Single photon emission tomography, Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (radionuclide imaging), Supranuclear ophthalmoplegia, Technique, Tomography, Emission-Computed, Single-Photon, hyperintense lesions, iodobenzamide, midbrain diameter, single photon emission computed tomography.
- MESH :
- chemical , diagnostic use : Benzamides, Dopamine Antagonists, Iodine Radioisotopes, Pyrrolidines.
- metabolism : Corpus Striatum, Receptors, Dopamine D2, Supranuclear Palsy, Progressive.
- pathology : Mesencephalon, Supranuclear Palsy, Progressive.
- radionuclide imaging : Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon.
Abstract
Patients with the clinical diagnosis of progressive supranuclear palsy (PSP) show heterogeneous neuropathological findings. In neuropathologically proven cases with numerous neurofibrillary tangles of neuropil threads, the brainstem and striatum are always affected. We compared 123I‐iodobenzamide single photon emission computed tomography (IBZM‐SPECT) for imaging of striatal dopamine D2 receptors in vivo with high‐resolution magnetic resonance imaging (MRI) in 13 patients with possible or probable PSP. Clinically, all patients exhibited similar signs including supranuclear vertical–down‐gaze palsy, axial rigidity especially involving the neck, bradykinesia, instability of balance with easy falls, and a poor response to dopaminergic drugs. Specific striatal dopamine D2 receptor binding in IBZM‐SPECT was reduced in 10 patients but was normal in three patients. Mean midbrain diameter was 23.7 mm. The reduction of IBZM‐binding was statistically significantly correlated to midbrain atrophy (P = 0.010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected. © 2002 Movement Disorder Society.
Url:
DOI: 10.1002/mds.10106
Affiliations:
- Allemagne
- Bade-Wurtemberg, Bavière, Berlin, District de Giessen, District de Haute-Bavière, District de Leipzig, District de Tübingen, Hesse (Land), Saxe (Land)
- Berlin, Leipzig, Marbourg, Munich, Ulm
- Université Louis-et-Maximilien de Munich, Université d'Ulm
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Le document en format XML
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sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Klinikum Grosshadern, Ludwig‐Maximilians‐Universität München, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiology, Klinikum Grosshadern, Ludwig‐Maximilians‐Universität München, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Klinikum Grosshadern, Ludwig‐Maximilians‐Universität München, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiology, Klinikum Grosshadern, Ludwig‐Maximilians‐Universität München, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-05">2002-05</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="557">557</biblScope><biblScope unit="page" to="562">562</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D6541695D4132ECCC8C4CC6206C9844A0CEAF436</idno><idno type="DOI">10.1002/mds.10106</idno><idno type="ArticleID">MDS10106</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antagonist</term><term>Atrophy</term><term>Benzamide derivatives</term><term>Benzamides (diagnostic use)</term><term>Corpus Striatum (metabolism)</term><term>D2 Dopamine receptor</term><term>Diagnosis</term><term>Dopamine Antagonists (diagnostic use)</term><term>Female</term><term>Humans</term><term>In vivo</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mesencephalon (pathology)</term><term>Middle Aged</term><term>Morphometry</term><term>Nuclear magnetic resonance imaging</term><term>Pyrrolidines (diagnostic use)</term><term>Receptors, Dopamine D2 (metabolism)</term><term>Severity of Illness Index</term><term>Single photon emission tomography</term><term>Supranuclear Palsy, Progressive (metabolism)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term><term>Supranuclear ophthalmoplegia</term><term>Technique</term><term>Tomography, Emission-Computed, Single-Photon</term><term>hyperintense lesions</term><term>iodobenzamide</term><term>midbrain diameter</term><term>single photon emission computed tomography</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Benzamides</term><term>Dopamine Antagonists</term><term>Iodine Radioisotopes</term><term>Pyrrolidines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Receptors, Dopamine D2</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mesencephalon</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Antagoniste</term><term>Atrophie</term><term>Benzamide dérivé</term><term>Diagnostic</term><term>Imagerie RMN</term><term>In vivo</term><term>Morphométrie</term><term>Ophtalmoplégie supranucléaire</term><term>Récepteur dopaminergique D2</term><term>Technique</term><term>Tomoscintigraphie émission monophotonique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with the clinical diagnosis of progressive supranuclear palsy (PSP) show heterogeneous neuropathological findings. In neuropathologically proven cases with numerous neurofibrillary tangles of neuropil threads, the brainstem and striatum are always affected. We compared 123I‐iodobenzamide single photon emission computed tomography (IBZM‐SPECT) for imaging of striatal dopamine D2 receptors in vivo with high‐resolution magnetic resonance imaging (MRI) in 13 patients with possible or probable PSP. Clinically, all patients exhibited similar signs including supranuclear vertical–down‐gaze palsy, axial rigidity especially involving the neck, bradykinesia, instability of balance with easy falls, and a poor response to dopaminergic drugs. Specific striatal dopamine D2 receptor binding in IBZM‐SPECT was reduced in 10 patients but was normal in three patients. Mean midbrain diameter was 23.7 mm. The reduction of IBZM‐binding was statistically significantly correlated to midbrain atrophy (P = 0.010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected. © 2002 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Berlin</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>District de Leipzig</li><li>District de Tübingen</li><li>Hesse (Land)</li><li>Saxe (Land)</li></region><settlement><li>Berlin</li><li>Leipzig</li><li>Marbourg</li><li>Munich</li><li>Ulm</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Arnold, Guy" sort="Arnold, Guy" uniqKey="Arnold G" first="Guy" last="Arnold">Guy Arnold</name></region><name sortKey="Arnold, Guy" sort="Arnold, Guy" uniqKey="Arnold G" first="Guy" last="Arnold">Guy Arnold</name><name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name><name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name><name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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